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KMID : 0665220080210030275
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Korean Journal of Food and Nutrition
2008 Volume.21 No. 3 p.275 ~ p.282
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Effect of Water Extracts from Root of Taraxacum officinale on Innate and Adaptive Immune Responses in Mice
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Yoon Taek-Joon
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Abstract
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Hot-water() and cold-water() extracts of Taraxacum officinale root were assessed for the effects of innate and adaptive immune responses in mice. Hot water extracts(TO-100) and cold water extracts(TO-4) did not affect the viability of macrophages at concentrations below to 18 mg/ml and 8 mg/ml, respectively. The thioglycollate-induced macrophages cultured with TO-100 and TO-4 produced a significantly higher quantity of various cytokines, such as IL-6 and IL-12, than those treated with medium. This shows that the extracts potently stimulated the innate immune response. When mice were subcutaneously immunized(sc) with OVA+FIA(Freund’s incomplete adjuvant)-emulsified TO-100, TO-100 did not affect the production of IgE, but enhanced the production of IgG1, IgG2a and IgG2b. The culture supernatant obtained from the splenocytes of mice treated with OVA+FIA-emulsified TO-100 also evidenced elevated levels of both OVA-specific Th1-type(IFN-) and Th2-type cytokines(IL-4, IL-6 and IL-10). These results suggested that TO-100 can modulate the immune responses to allergens in mice.
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KEYWORD
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Taraxacum officinale, innate and adaptive immunity, antibody, cytokine
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